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People with Digestive Issues Certain gut conditions can hinder B12 absorption, for example, Crohns disease and celiac disease

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A dedicated phase 3 RENEW trial which investigates the efficacy and safety of the drug in patients with obesity or who were overweight, but without associated comorbidities is scheduled to start in late 2025.

Patients typically start at injecting 1ml IM or SQ one to two times per week, and can titrate up or down by 0.5ml per dose depending on effectiveness and side effects